Hadronic final states in e+e- annihilation are studied using the Four-Jet Rate. This observable is sensitive to final states with at least four partons. We use data from the OPAL experiment ranging from sqrt(s) = 91 to 207 GeV. Perturbative QCD calculations in NLO combined with NLLA calculations are compared with the data and the strong coupling constant alpha_s, the main parameter of QCD, is extracted.